Gene information
Official symbol CTSS
Official full name cathepsin S
Gene type protein-coding gene
Chromosome1q21.3
Gene familyCathepsins
Resources
Entrez Gene 1520
HGNC HGNC:2545
Ensembl ENSG00000163131
Vega OTTHUMG00000035010
UCSC uc001evn.3
GO terms: 54 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001968 fibronectin binding GO Molecular Functions -9.79576986 9 More
GO:0002221 pattern recognition receptor signaling pathway GO Biological Processes -6.97185167 18 More
GO:0002224 toll-like receptor signaling pathway GO Biological Processes -4.97797298 7 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002478 antigen processing and presentation of exogenous peptide antigen GO Biological Processes -1.87435466 3 More
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO Biological Processes -2.08003997 3 More
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO Biological Processes -2.04281609 3 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005518 collagen binding GO Molecular Functions -7.71267127 10 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019882 antigen processing and presentation GO Biological Processes -2.12014641 5 More
GO:0019884 antigen processing and presentation of exogenous antigen GO Biological Processes -1.62783208 3 More
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO Biological Processes -2.15864942 3 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031904 endosome lumen GO Cellular Components -9.27147512 9 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043202 lysosomal lumen GO Cellular Components -6.22272327 10 More
GO:0043236 laminin binding GO Molecular Functions -4.54309219 5 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043394 proteoglycan binding GO Molecular Functions -12.1259478 11 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045335 phagocytic vesicle GO Cellular Components -3.63275570 16 More
GO:0048002 antigen processing and presentation of peptide antigen GO Biological Processes -2.10223243 4 More
GO:0050840 extracellular matrix binding GO Molecular Functions -6.18341292 8 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0071711 basement membrane organization GO Biological Processes -3.03394175 6 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904724 tertiary granule lumen GO Cellular Components -12.6232675 13 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
GO:2001257 regulation of cation channel activity GO Biological Processes -11.2578208 33 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04142 Lysosome KEGG Pathway -1.52242432 5 More
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
petesicatib inhibitor TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cathepsin S proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Befekadu R et al. Cardiol J. 2019
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